Mozambique Rolls Out Twice-Yearly HIV Prevention Shot

A new HIV prevention shot that works with just two injections a year is now available in Mozambique, offering hope to thousands of young people at risk.

Health Minister Ussene Isse announced the launch of lenacapavir on Wednesday in Matola, calling it a milestone in the country's fight against HIV. The long-acting injectable reduces the risk of HIV infection by more than 99%, giving people a powerful new way to protect themselves.

Unlike daily pills, lenacapavir only requires an injection twice a year. It's approved for people 15 and older, making it especially valuable for adolescents and young adults who face the highest risk.

The timing couldn't be more critical. Mozambique recorded about 92,000 new HIV infections in 2024 alone. Of those, 15,000 occurred among young people between ages 10 and 19.

"From today, Mozambique joins the group of pioneering countries that provide their citizens with an injectable drug capable of reducing the risk of HIV infection by more than 99%," Isse said at the launch ceremony. The medication joins other prevention tools already available, giving people more choices to fit their lifestyles and needs.

The rollout builds on lessons learned from a pilot program in Nampula province last year. Health officials tested a similar injectable called cabotegravir to prepare for this larger launch.

The Ripple Effect

The medication will initially reach 55 health facilities across three regions: Zambézia province, Maputo city, and Maputo province. This phased approach covers 15 districts where prevention efforts can make the biggest difference.

Mozambique joins a small but growing group of African nations embracing this technology. Eswatini, Zambia, and Zimbabwe have already started offering lenacapavir to their citizens, creating a regional network of countries working together to end new HIV infections.

Gilion Michila, Matola's district administrator, encouraged everyone to learn about the new option. "We invite our population to seek information, talk to health professionals, and share knowledge with family and friends," she said. "Every informed decision can change a life."

The twice-yearly schedule removes one of the biggest barriers to HIV prevention: remembering daily medication. For young people juggling school, work, and social lives, this simplicity could mean the difference between staying protected and falling through the cracks.

As more health facilities get trained and stocked with lenacapavir, thousands of Mozambicans will have access to protection that fits seamlessly into their lives.